An average cancer cell is driven by 5–10 mutations, roughly similar to the number of proteins encoded by an average virus. Transformation or viral infection reconfigures cellular phenotype, but the logic of either complex perturbation is difficult to explain by inspection and intuition. Our laboratory tackles these challenges with a systems bioengineering approach that combines quantitative measurements, computational models, experimental manipulations, and data mining. We pursue systems bioengineering research that scales from genes and proteins in cells to tissues and tumors in animals to large-scale observations in human populations. Explanatory and predictive understanding at the systems level will one day lead to therapeutic strategies that are innovative and tailored to the complexity of each disease.
Mailing address
Box 800759, Health System
Charlottesville, VA 22908
Charlottesville, VA 22908
Shipping address
415 Lane Road, MR5-Rm. 2225
Charlottesville, VA 22908
Charlottesville, VA 22908
scientific inquiries
Kevin Janes
Department of Biomedical Engineering
University of Virginia
kjanes@virginia.edu
Phone: 434-243-2126 (office)
Fax: 434-982-3870
Department of Biomedical Engineering
University of Virginia
kjanes@virginia.edu
Phone: 434-243-2126 (office)
Fax: 434-982-3870
general inquiries
Cheryl Borgman
Department of Biomedical Engineering
University of Virginia
cab9e@virginia.edu
Phone: 434-243-1733 (lab)
Fax: 434-982-3870
Department of Biomedical Engineering
University of Virginia
cab9e@virginia.edu
Phone: 434-243-1733 (lab)
Fax: 434-982-3870
affiliations
- UVA Department of Biomedical Engineering
- UVA Comprehensive Cancer Center
- Robert M. Berne Cardiovascular Research Center
- Center for Public Health Genomics
- UVA Training Program in Cancer Biology
- UVA Medical Scientist Training Program
- UVA Biotechology Training Program
- UVA Cardiovascular Training Program
- UVA Pharmacological Sciences Training Program