Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response.

/in /by
Ung J, Tan SF, Shaw JJP, Taori M, Deddens TM, Venancio GDC, Montgomery MM, Hagen JT, Aruleba RT, Golla UR, Sharma A, Paudel BB, Lee IS, Ramamoorthy B, Janes KA, Garrett-Bakelman F, Cabot MC, Fisher-Wellman KH, Fox TE, Claxton DF, Chalfant CE, Feith DJ, Loughran TP. (2025) Acid ceramidase inhibition enhances BCL-2 targeting in venetoclax-resistant acute myeloid leukemia via a cytotoxic integrated stress response. bioRxiv doi: 10.1101/2025.06.06.657881. [Article]